Description
Product Characteristics: Transcription factor which acts as both an activator and repressor. Binds the CACCC core sequence. Binds to multiple sites in the 5'-flanking region of its own gene and can activate its own transcription. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development.
Cellular Localization: Nucleus
Target Information: a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene [RGD, Feb 2006]